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Derived from the amino acid, histidine, histamine is a bioactive amine that helps with several key cellular functions
Hilali, S
Erring on the side of caution is appropriate
Because the unusual bond formed through the gamma-carboxyl group of glutamate can only be hydrolyzed by one enzyme, gamma-glutamyltranspeptidase, which is present only on the external surfaces of certain cells
Up to now, powerful genetic tools allowed clarification of the significance, dispensability and potential of cystine transporters for ferroptotic cell death in PDAC and breast cancer ( via xCT ( A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport ( in vitro studies as efficient inducer of ferroptosis in many different cancer types, including breast, PDAC, lymphoma, renal, brain and ovarian cancers ( via transsulfuration pathway is a potential resistance mechanism under cysteine depletion conditions
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