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Quick Answer: GLP-1 medications typically cause modest blood pressure reductions of 2-6 mmHg, but some patients may experience symptomatic low blood pressure, particularly when combined with antihypertensive medications, significant weight loss, or dehydration from gastrointestinal side effects

Action in Diabetes 5 met (2009) Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial

Clinical considerations for delayed dosing include the potential for breakthrough hyperglycemia in patients with diabetes and increased appetite in those using semaglutide for weight management

Furthermore, tolerability issues require effective gastrointestinal side effect mitigation, as these are a primary reason for cessation

it minimizes gastrointestinal side effects and allows your metabolism to adjust to a lower caloric intake