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Observations of variable lean mass outcomes and dietary shifts during GLP-1RA therapy [40, 75] suggest that substrate availability may influence therapeutic durability even in the absence of overt deficiency
Given the stable HRs across the spectrum of frailty, these differences in number needed to treat between frail and non-frail people are primarily driven by the higher number of events among frail patients, which highlights the greater vulnerability of this population. Lower CV risk with SGLT2 inhibitors vs
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