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Retatrutide (triple agonist, investigational) Retatrutide is a triple hormone receptor agonist targeting GLP-1, GIP, and glucagon receptors
It is made from amino acids and is present in many cells, where it helps protect them from oxidative stress
In prospective data, 87% tolerated the transition without significant GI symptoms and only 2% discontinued
Then it is eliminated by liver metabolism and renal excretion [7]
ClinicalTrials.gov: NCT05929066 (TRIUMPH-1), NCT05929079 (TRIUMPH-2), NCT05882045 (TRIUMPH-3), NCT05931367 (TRIUMPH-4), NCT06383390 (TRIUMPH-Outcomes), NCT06354660 (TRANSCEND-T2D-1)
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