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Animal models provide some insight but limited applicability

Mitch Biermann, an obesity medicine physician at Scripps Health in San Diego, said the practice is emblematic of a wider shift in his field, toward a more holistic assessment of excess fat and body composition

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However, NICE does not recommend its routine use in drug-induced weight loss contexts (only in bariatric surgery under specific protocols)

31 Heme can also adjust the target gene transcriptions in various pathways, such as circadian rhythm, cell proliferation, apoptosis, antioxidant stress response, ion channel activity, and mitochondrial respiration