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IGF-I deficiency is associated with growth hormone insensitivity syndrome (GHIS) also called Laron syndrome, liver cirrhosis, age-related cardiovascular and neurological diseases, and intrauterine growth restriction

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So blood tests, because we know the research is clear that if it is sub-therapeutic levels, even if she's not having hot flashes, [00:40:00] we shouldn't be expecting the full metabolic benefit

In the pig LR3 IGF-1 study, plasma endogenous IGF-1 was suppressed during infusion (Tomas et al., 1997), and the guinea pig study showed reduced plasma IGF-I and IGF-II during LR3 administration (Bastian et al., 1995)