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Transparency about the regulatory status of the treatment : A responsible doctor will clearly explain whether a proposed treatment is HSA-approved for its intended use, or whether it constitutes off-label use, and will document informed consent accordingly

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Some seemingly non-antibiotic substances have shown positive outcomes as they have bactericidal properties or increase the susceptibility of MDR bacteria toward antibiotics and the hosts immune response in Fig

Blood flow regulation: It may encourage angiogenesis, or the formation of new blood vessels, and support circulation in localized areas

Pre-clinical IR intervention mainly includes drug intervention, probiotic therapy and exercise supplement