The fat pads in the mid face start to shrink which causes a loss of key volume in your face
So you're absolutely right about that
While the mid-regions of both peptides interact with the top of TM1/ECD stalk, the ECD, ECL1 and the top of TM2, exendin-4 exhibits more persistent interactions in the simulations, particularly with the TM1/stalk and ECD (Supplementary Tables 1 and 3)
Learn more: #glp #weightloss #eatingdisorders The question is bigger than whether people eat less
Front Pharmacol 9:1535 Dodd J, Jordan R, Makhlina M, Barnett K, Roffel A, Spana C et al (2023) A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans