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The convergent/parallel amino acid site 42 was located at the beta-strand position, site 93 was located at the turn position, and site 513 was located close to the modified residue site (511, 515)

doi: 10.1016/j.cell.2024.06.003 124 RosenkildeMMLindquistPKizilkayaHSGasbjergLS

Weekly weight loss visits to include vitals, weigh in, discuss food log, discuss difficulties and ways to overcome them, meet with NP to get injections Semaglutide subQ injection .25mg B12 IM injection .5mg LIpolight treatment 15 minutes Begin mild exercise such as walking for 20 min 3-5 days/week (HR about 120) Weekly visit same as above Semaglutide subQ injection .5mg B12 IM injection .5 mg Lipolight treatment 20 min Continue mild exercise and increase to 30 min at least 5 days/week (HR about 120) Weekly visit same as above include vitals, weigh in, meet with NP Semaglutide subQ injection 1mg B12 IM injection .5 mg Lipolight treatment 25 min Begin moderate exercise 30 min 3-5 days/week (HR about 135) Weekly visit same as above include vitals, weigh in, meet with NP Semaglutide subQ injection 1.7mg B12 IM injection 1mg Lipolight treatment 25 min Continue moderate exercise 30 min each day (HR about 135) Everything the same as above Semaglutide subQ injection 2.4mg Prescription for Semaglutide 2.4mg weekly injection sent to pharmacy if needed Schedule 3 month follow up weigh in to ensure maintaining weight loss

GLP-1 receptor agonists mimic that hormone to reduce appetite and, in the approved agents, support weight management and glucose control