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They feed the gut bacteria that produce short-chain fatty acids, which in turn stimulate GLP-1 secretion
Moreover, GLP-1R cascade also has interactions to regulatory proteins involved in the insulin receptor cascades such as the insulin receptor substrates (IRS) and the PI3K involved in the positive regulation for survival, metabolism and proliferation of beta pancreatic cells as well as apical glucose transport in peripheral tissues
Active-duty members with obesity but no diabetes cannot get Zepbound through TRICARE
GLP-1 drugs have been used by large shares of adults who say they have been diagnosed with diabetes (57% have ever used the drug, including 45% who are currently using), heart disease (40% ever, 29% currently), or as obese or overweight in the past five years (34% ever, 23% currently)
Given that Cignas own leadership frames its internal policy change as driven by the exact same set of challenges facing its clients, this downtick may signal a more widespread pullback in employer-sponsored GLP-1 weight-loss coverage across the industry, not just within Cignas own client base
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