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Dose-dependent effect of 2-deoxy-D-glucose on glycoprotein mannosylation in cancer cells

GSH depletion lowered IC 50 values for both AQ-QI (from 54 to 20 M) and DEAQ-QI (from 40 to 18 M)

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Mechanism and Rapid Onset (Panel 1) : Succinylcholine triggers a Phase I depolarizing blockade by mimicking acetylcholine, leading to initial muscle fasciculations followed by prolonged membrane depolarization and flaccid paralysis