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A small but significant portion undergoes cytochrome P450 (CYP2E1) oxidation, producing the reactive intermediate N-acetyl-p-benzoquinone imine (NAPQI)
The enzymes responsible for this digestion (pepsin in the stomach, trypsin and chymotrypsin from the pancreas in the small intestine) are highly efficient and rapidly degrade most therapeutic peptides to pharmacologically inactive fragments before they can act on mucosal tissue
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