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Epub 2014 Sep 11

Given TB-500s pleiotropic biology across multiple tissue types and cell populations, peptide impurities could introduce confounding biological signals across the broad range of assay systems in which TB-500 is studied , making high purity verification particularly important for research designs involving multiple endpoints or comparative studies

4 If these indications continue to broaden and adoption scales accordingly, the cumulative impact on public health could be profound

SAFETY SIGNALS Twenty-eight-day intramuscular dosing in rats and dogs produced what FDA called clinically relevant safety signals: altered activated partial thromboplastin time and liver-associated changes (ALT, glucose, triglycerides)