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Ethics declarations Conflict of interest SC received lecture or consultancy fees from AstraZeneca, Boehringer Ingelheim, Eli Lilly, MSD, Novo Nordisk

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The fatty part of the frontal abdomen below the ribs, above the hips, and not directly adjacent to the belly button

188 The synthetic lethality paradigm remains central, exemplified by the success of PARP inhibitors in HRR-deficient tumors