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US survey data from the NHANES What We Eat in America 2013e16 cohort reported the median vitamin B12 consumption for all adult men of 5.1 mcg and women of 3.5 mcg.95b Using the Estimated Average Requirement (EAR) for adults for Vitamin B12 of 2 mcg,93 less than 3% of men and 8% of women in the United States had inadequate diets using this comparator

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A deficiency in vitamin B12 can result in significant health problems, including anemia, neurological disorders, and impaired immune function

Whilst B12 injections are well-established NHS treatments for documented deficiency, lipotropic combinations lack robust clinical evidence and are not routinely prescribed within the NHS