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Since the pool of circulating transferrin iron amounts to 3 mg, the rate of iron turnover by these cells is quite high (8 to 10 times)
Everything below is either preclinical animal work, a theoretical concern drawn from the proposed mechanism, or self-reported community anecdote each labeled by source class so the evidence weight is never blurred
In C57BL/6J mice given intravitreal injection of ferric ammonium citrate (FAC), which prompted the accumulation of LPO carboxyethyl pyrrole in RPE cells, these cells died in patches and then expanded at the borders (83)
The carbohydrate moieties on viral S-protein surface could facilitate viral internalization via innate immune factors, such as neuropilin (NRP)-1, C-lectin type receptors (CLR), and toll-like receptors (TLR), as well as the non-immune receptor glucose-regulated protein 78 (GRP78) for systemic spread of infection 61
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