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But the same location in the peroxidase enzymes is blocked by the protein structure so that substrates can interact only with the heme edge

Treatment regimens and guidance: The British National Formulary (BNF) and NICE Clinical Knowledge Summaries outline treatment regimens for B12 deficiency

doi:10.1016/0891-5849(88)90109-8

However, continuous taking COCP might increase the risk of venous and arterial thrombosis and elevate C-reactive protein (CRP) levels which cause cardiovascular diseases [50]