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Analysis of blood biomarkers of liver and kidney damage Biomarkers of liver damage (alanine transaminase and aspartate transaminase), kidney damage (creatinine and blood urea nitrogen), as well as albumin concentrations in mouse plasma were measured using the Piccolo Xpress Chemistry Analyzer (Hitado, Germany)

inclusion criteria, follow-up period) (16), but it could be also due to peculiar and still unknown effects of each drug

The mechanism involves upregulation of tissue inhibitors of metalloproteinases (TIMPs) and simultaneous downregulation of matrix metalloproteinases (MMPs), shifting the extracellular matrix balance toward net deposition rather than degradation

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Braidy, N., Berg, J., Clement, J., Khorshidi, F., Poljak, A., Jayasena, T., Grant, R., & Sachdev, P