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The GLP-1 drives fat loss and metabolic improvement while sermorelin/tesamorelin preserve and build lean masspreventing the muscle loss that often accompanies rapid weight loss
In clinical studies, tirzepatide led to substantial weight loss and improved blood sugar control in people with excess weight and type 2 diabetes
While studies that focus on weight loss specifically have used doses of 2.4 mg of semaglutide, the lower doses provided by Ozempic appear likely to retain significant weight loss potential
In one study, a single injection of dulaglutide lowered fasting glucose by about 20 mg/dL (1.1 mmol/L), and after-meal glucose levels by about 30 to 50 mg/dL (1.67 to 2.78 mmol/L), compared to the same peoples measurements before taking dulaglutide
IGF-1 DES acts downstream, interacting directly with target tissue receptors
