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Semaglutide: The following are rare but serious side effects of semaglutide: Thyroid C-Cell Tumors: Semaglutide has a boxed warning for thyroid tumors based on animal studies

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Common side effects: Nausea Vomiting Diarrhea Constipation Mild abdominal discomfort Why side effects occur: These issues are most likely during the dose escalation phase, which is why the stepwise tirzepatide dosing schedule is so important