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dose-dependent GI adverse events (nausea, vomiting) similar to other amylin analogues Exposure: Dose-proportional increases in Cmax and AUC Gastric Effects: Dose-dependent slowing of gastric emptying confirmed via paracetamol absorption test Appetite Suppression: Reduced ad libitum food intake at doses 1.2 mg Clinical Significance: Established feasibility of once-weekly dosing and identified dose range for Phase 2 studies
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This form is well-absorbed, highly bioavailable, and more stable throughout the digestive tract than other forms on the market
Lactic acidosis in biguanide-treated diabetics: a review of 330 cases
31 In OVX insulin-deficient streptozotocin (STZ) diabetic rats, liraglutide significantly lowered serum CTX-I levels and inhibited osteoclast differentiation
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