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In the LC3 lipidation pathway, Atg4 cleaves the LC3 precursor to generate LC3-I, which is then covalently linked by Atg7 to Atg3, forming membrane-anchored LC3-II that integrates into the autophagosome membrane, promoting membrane extension and serving as a marker for substrate recognition, thereby facilitating targeted transport (30)
SURPASS-CVOT (N=13,165) noninferior on 3-point MACE (HR 0.92), with 4-point MACE HR 0.88 and all-cause death HR 0.84: Heerspink SURPASS-4 kidney post-hoc
Especially if youre combining infusion therapy with aesthetic treatments or weight loss programs
Fluorescence images were sequentially acquired with a Nikon A1R+ laser scanning confocal Eclipse Ti-E inverted microscope (Nikon Corporation, Tokyo, Japan) equipped with a motorized stage (TI-S-E, Nikon)
