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The disease affects a vital group of cells: retinal pigment epithelium (RPE) cells
Toxicity mediated by reactive metabolites of furans
It has been shown that roGFP2 is almost fully reduced in intact tissues and that a treatment with the GSH1 inhibitor BSO or the electrophilic xenobiotic 1-chloro-2,4-dinitrobenzene led to fully oxidized state of the biosensor accompanied by decreased fluorescence intensity 52
Synergistic upregulation of energy metabolism and insulin signaling genes: Salic et al
(2017) Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone Tipton KD, Wolfe RR
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