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Activated HIF-1 enters the cell nucleus, where it binds to the promoters of the xanthine dehydrogenase (XDH) and 5-nucleotidase II (NT5C2) genes, thereby upregulating the expression of XDH and NT5C2
They also exhibit lower incidences of cancer and extended lifespans [3]
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), which were initially approved for the treatment of type 2 diabetes (T2D) and obesity, have cardiovascular benefits that extend beyond glycaemic control
7 Notably, the Standards of Care emphasize a shared decision-making approach in which patients and caregivers are actively involved in care decisions as integral members of the care team
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