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These preclinical insights have been validated in large-scale clinical trials.The FLOW trial (n = 3,533) showed that once-weekly subcutaneous administration of semaglutide (1.0 mg) significantly reduced the risk of a renal composite endpointincluding 50% decline in eGFR, renal failure, or cardiovascular deathby 24% in patients with T2DM and chronic kidney disease (CKD) (HR = 0.76, 95% CI: 0.660.88
Monitor heart rates in Saxenda-treated patients and discontinue therapy if sustained increases occur Suicidal behavior and ideation In adult trials, 0.3% of Saxenda-treated patients reported suicidal ideation compared to 0.1% of placebo-treated patients
Liver disease and protein needs
No significant systemic copper elevation has been reported from topical application in healthy adults
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