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Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for type 2 diabetes management in adults (Mounjaro) and chronic weight management (Zepbound) in adults with BMI 30 kg/m or 27 kg/m with at least one weight-related comorbidity
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In this model, the stimulus ligand ( The dynamics of this signaling pathway can be simulated using a set of four equations (equations 14), where each equation describes the temporal change of one of the main signaling components (see Appendix Note S1 part 1 for extended descriptions)
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