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Oxygen and glucose deprivation (OGD) mimics ischemic stroke-induced hyper-permeability of HBMECs due to internalization of VE-cadherin and is dependent on activation of the RhoA/Rock pathway (Chen et al., 2+ in BECs and pericytes and was correlated with the loss of TJs, AJs, increased BBB permeability, and pericyte death (Imai et al., 2019)
Claim Strength Matrix for Skin, Hair, and Healing Claims Skin aging claims are moderate when limited to topical cosmetic outcomes, wound-healing claims are context-dependent because evidence includes both human diabetic-ulcer research and animal models, and hair growth claims remain preliminary or indirect [2], [3], [6], [13]
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Transcriptional regulation of the human cystathionine beta-synthase -1b basal promoter: synergistic transactivation by transcription factors NF-Y and Sp1/Sp3
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