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Strengths include its pragmatic, head-to-head crossover design, which allows within-patient comparisons and direct ranking of therapies in real-world settings, and inclusion of multiple common regimens enhancing external validity
Enzymatic cleavage of secreted PYY 136 at the amino terminal by the enzyme dipeptidyl peptidase IV (DPP-IV) gives rise to PYY 336 [8], the predominant form of circulating PYY
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A more sensitive method extends detectability without altering the half-life
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