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CJC-1295 with DAC (Drug Affinity Complex) contains a maleimide-lysine side chain that covalently binds albumin in plasma, extending the half-life to approximately 6-8 days [4]
Upon reaching either of the cell surfaces, the receptor:ligand complex is exposed to the physiological pH of 7.4 in the extracellular milieu, which triggers ligand release [78]
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