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Dihexa-based compounds do not interact with central or peripheral AT 1 receptors, are highly target specific, exhibit little interaction with cardiac channel proteins and hepatic CIP isoforms, and reveal no acute toxicity following a 6x effective dose of Dihexa
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A 2025 Frontiers in Physiology study demonstrated that MOTS-c restores mitochondrial respiration in type 2 diabetic hearts
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