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Lyophilization dramatically improves shelf stability because peptides in solution are vulnerable to hydrolysis, oxidation, aggregation, and microbial growth, whereas a dry powder can remain stable for months or years when kept cold and sealed
This may become particularly important for adults with type 2 diabetes
On the other hand, much evidence from large retrospective cohorts with endoscopic evaluation of gastric content has proven the association between incretin-based therapy exposure and increased retained gastric content [21]
We thank Qingtong Zhou and Yuxia Wang for their assistence in model analysis or protein preparation, and Angela Walker for assistance with manuscript preparation
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