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PMC 10896480
Overexpression of the cyclin B1-CDC2 complex stimulates cell division in adult mouse cardiomyocytes, and deficiency of the cyclin B1-CDC2 complex results in adult mouse cardiomyocytes remaining in the G2/M phase and inhibits cardiomyocyte proliferation (83)
This comprehensive strategy prevents the metabolic pushback commonly seen with single-target therapies
Safety and efficacy analyses across age and body mass index subgroups in East Asian participants with type 2 diabetes in the phase 3 tirzepatide studies (SURPASS programme)
The results of the power calculations are shown in Additional file 1: Table S6 [38, 39]
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