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But you should be careful of them

For patients who experience significant GI side effects at standard titration rates, a slower escalation using a lower starting concentration can make treatment more tolerable and improve long-term adherence

Reconstitution and administration determine whether the intended protocol is being delivered

J Biol Chem 2000

This regulatory mechanism explains the so-called arginine paradox, which refers to the phenomenon where extracellular L-arginine availability influences NO production despite the saturation of NOS enzymes with intracellular arginine