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The established Observed Safe Level (OSL) for chronic, long-term supplementation is generally recognized as 2,000 mg per day, though higher doses have been used safely in monitored trials

As well, VD supplementation can modulate oxidative stress parameters by reducing nitric oxide (NO), increasing glutathione (GSH) expression, and improving the total antioxidant capacity (63)

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However, the critical limitation remains the near-complete absence of human clinical trial data