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Birth issues: The FDA recommends GLP-1s not be taken during pregnancy and be discontinued at least two months prior to pregnancy, because animal studies demonstrate it may cause higher rates of miscarriage and birth defects

Researchers and writers often position it as the cleaner or more targeted option

345,346 GLP-1 may also reduce the expression of cartilage-degrading enzymes by inhibiting the MAPK pathway or activating anti-inflammatory pathways such as PI3K/Akt, thereby alleviating cartilage damage

Image Credit: fizkes/Shutterstock.com Metabolic and hormonal effects GLP-1 RAs have emerged as promising therapeutic agents in managing metabolic and hormonal disturbances in PCOS