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We identified downregulation of mitochondrial programs in multiple non-proximal tubular cell populations compared with their counterparts in healthy kidneys

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[1] Shabert JK, Winslow C, Lacey JM, Wilmore DW

This review concluded that intakes up to 2 g/day are safe for chronic supplementation. An International Olympic Committee (IOC) statement on dietary supplements for high-performance athletes stated that No negative health effects are noted with long-term use of creatine

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