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Clinical Uses: Nausea & vomiting (postoperative, drug-induced, migraine-associated) Diabetic gastroparesis Gastroesophageal reflux disease (GERD) Facilitation of small-bowel intubation Adverse Effects: Extrapyramidal symptoms (EPS) such as dystonia, tremors Drowsiness, restlessness Long-term use Tardive dyskinesia Contraindicated in Parkinsons disease & bowel obstruction Clinical Tip: Use short-term (12 weeks) when possible