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Contraindications to ospemifene use include 35 undiagnosed abnormal genital bleeding estrogen-dependent neoplasia hypersensitivity to ospemifene active or history of deep vein thrombosis or pulmonary embolism active or history of arterial thromboembolic disease (e.g., stroke, myocardial infarction) Women taking ospemifene should not take estrogen or estrogen agonist/antagonists, fluconazole, or rifampin concomitantly