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IgG3 and IgG2 are notably transcytosed less efficiently than IgG1 and IgG4 [84], likely because of a missing glycine in the lower hinge of IgG2 [338] and an arginine instead of a histidine in amino acid position 435 in IgG3 [339, 340]
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Various treatments also exist to remove unattractive superficial veins, depending on their size: For spider veins and smaller varicose veins: foam or liquid sclerotherapy, as long as there are abnormalities affecting the major veins For saphenous vein insufficiency: Destruction via endovenous thermal ablation Removal through surgical vein stripping and/or phlebectomy Preservation by restructuring the venous pathways: strategic points, identified prior to the procedure via Doppler ultrasound, are tied off (CHIVA technique)
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10.1111/dom.12812 128 XianH.LiuY.Rundberg NilssonA.GatchalianR.CrotherT
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