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39 As shown in the LEADER study (NCT01179048), the secondary composite outcome of persistent doubling of the serum creatinine level, new-onset persistent macroalbuminuria, end-stage renal disease or death due to renal disease occurred significantly less frequently in the treatment group than in the placebo group, with a hazard ratio of 0.78

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For cultured cells, a protocol similar to that for skin sections was followed but replicate 20 images were used

That means taking an active approach and consciously changing your diet to exclude the types of foods that spike insulin and make PCOS worse