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As more individuals of reproductive age use these medications, questions arise about their potential impact on fertility

A second variant, rs10305420 (Pro7Leu), affects the signal peptide of GLP1R and may reduce receptor trafficking to the cell surface

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Subsequently, a 10-week, once-daily, multiple-dose trial in healthy males and males with T2D was conducted to evaluate the safety, pharmacokinetics and pharmacodynamics of oral semaglutide at steady state (multiple-dose trial)