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Your skin acts as a protective barrier, and even if small amounts of these compounds did get absorbed, research doesnt support that they would have any appetite-suppressing effects

References: Smith, R

Some users develop chronic constipation requiring fiber supplementation, increased water intake, or occasional use of osmotic laxatives like polyethylene glycol

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b , PrediXcan-based TWAS design in UK biobank and summary graph of SLC25A39 -associated phenotypes