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Recent guidelines suggest considering surgery at lower BMI thresholds (30 kg/m) for patients with type 2 diabetes

- TRIUMPH-3: Retatrutide in adults with obesity/overweight + established cardiovascular disease

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Protocol 3: the twice-weekly split dose approach Goal: Flatten the concentration curve to eliminate end-of-week symptom return Schedule (any compounded GLP-1): Take half your weekly dose every 3.5 days (e.g., Monday morning and Thursday evening) Total weekly dose remains identical Escalate total weekly dose at the same rate as your original plan Why the plotter supports this: The plotter shows a dramatic difference between once-weekly and twice-weekly dosing curves at the same total weekly dose