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In addition to the hepatic cholesterol excretion pathway, the ABG5/G8 heterodimer promotes cholesterol excretion from the intestinal cells directly to the intestinal lumen
To further enhance the BBB properties of the models, the medium was supplemented with cARLA (250 M 8-(4-chlorophenylthio)adenosine 3,5-cyclic monophosphate sodium salt, 17.5 M Ro-20-1724, 3 mM LiCl, 3 M A83-01
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The findings are significant because they unite several major themes in Parkinsons research: intestinal dysbiosis, systemic inflammation, immune signaling, oxidative stress, and neuronal iron toxicity