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In the presence of acetyl-CoA carboxylase (ACC), cytoplasmic acetyl-CoA is carboxylated to malonyl coenzyme A, which is further converted to FA by FASN, and both of these key enzymes are transcriptionally regulated by sterol regulatory element binding proteins 1 and 2 (SREBP1/2) [209]
Bhatwadekar AD, et al
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