what is more effective for weight loss semaglutide or tirzepatide works better me than vs. Semaglutide: Which Better? – New Leaf Online semaglutide works better for me – Tirzepatide vs semaglutide for weight

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Patients should understand that blood pressure changes may occur but that they should never independently discontinue prescribed antihypertensive medications

Mechanisms hypothesised to underlie blood pressure reduction with tirzepatide include: Weight reduction : Loss of adipose tissue decreases sympathetic nervous system activity, reduces cardiac output, and improves insulin sensitivityall contributing to lower blood pressure Natriuresis : GLP-1 receptor activation may promote sodium excretion through renal effects, though direct evidence for tirzepatide is limited [10] Improved endothelial function : Weight loss and metabolic improvements may enhance vascular health Reduced inflammation : Adipose tissue reduction decreases pro-inflammatory cytokines that may contribute to hypertension It is important to note that whilst the blood pressure reductions are consistent across trials, tirzepatide is not licensed as an antihypertensive agent