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Increasing feelings of fullness and slowing down gastric emptying, it helps you eat less without feeling constantly hungry
Some patients report constipation, bloating, or nausea during the first weeks of treatment, while others experience looser stools
Patients with Lebers disease should avoid using it also
This allows assessment of tolerance and response before increasing
Given the observed hydrogen-bonding interactions with Q726 and Y524 and considering the contribution of the P-clamp region to PDE10A selectivity, future optimization should prioritize (i) enhancing potency by incorporating structural constraints that properly orient key substituents to reinforce the Q726/Y524 hydrogen-bond network and (ii) modulating lipophilicity and polar surface area to achieve an optimal balance between CNS penetration and effective P-clamp engagement
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