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Before you use "Semaglutide vs Contrave: GLP-1 vs Naltrexone/Bupropion" to make a real decision, separate the headline answer from the details that could change it
Jun 21 2023;15(13)doi:10.3390/nu15132823 Pusceddu I, Herrmann W, Kleber ME, et al
Results vary based on starting weight, diet, activity level, and individual GLP1R sensitivity
Our findings offer comprehensive real-world evidence for the cardiovascular effectiveness of tirzepatide in clinical practice in the absence of studies with direct comparisons to semaglutide, and ahead of further evidence from the SURPASS-CVOT randomized controlled trial that compared tirzepatide against an older GLP-1 receptor agonist that is not frequently used in routine care 14,17
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