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Semaglutide (Wegovy/Ozempic) is the closest currently available alternative, producing 14-16% average weight loss compared to tirzepatide at 18-22%
Winter SC, Szabo-Aczel S, Curry CJ, Hutchinson HT, Hogue R, Shug A: Plasma carnitine deficiency
Valproate-induced hepatoxicity: protective effect of L-carnitine supplementation [PMID: 2124297] Laboratory literature summary: Valproate-induced hepatoxicity: protective effect of L-carnitine supplementation
And the landmark trials proved it works in humans
Cancer risk : IGF-1 has been linked to the growth of cancer cells in some studies, though more research is needed to fully understand the risks
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