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The committee's votes have been closely watched by the industry as they could signal a change in direction following the FDA's earlier concerns about these substances

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Blood samples were collected via cardiac puncture for biochemical analysis

1987 Jan;184(1):113-7

Increases in cGMP result in the inhibition of plasma membrane localized L-type Ca 2+ channels resulting in decreasing overall intracellular Ca 2+ which normally serves to activate myosin light chain kinase leading to vasoconstriction